Quick practical advice

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1/ If a physician or salesman shows you a vial with colored water, the vial will not contain any live cells. Cells can be seen with naked normal eye since they are stuck together in clusters.

2/ If someone shows you a ‘vintage’ vial covered with dust and cobwebs containing a beige powder, such vial will not contain any live cells. Live cells do not look like powder.

3/ If someone shows you a vial with frozen cells ask a question if they are primitively ‘flash frozen’ or frozen by a cryo-expert using appropriate cryopreservative cocktail. The survival of cells not frozen correctly is minimal, and the damage is multiplied if improper defrosting/thawing of cells is used: 95% of cells will be dead at the time of implantation. It is rumored that a smuggler convinced U.S. Customs officer and U.S. FDA agent that the huge quantity of flash frozen cells in her luggage were medicine for personal use for 90 days, supported by a prescription from a Mexican physician, as permitted to import to U.S. by the constitutional right of each citizen. When the cells reached U.S.A., they were partially thawed and by the time of implantation they were already rotting.

4/ It is extremely important to investigate the method of preparation of ‘stem cell transplants’ to be used for your treatment which clearly has not been done in U.S. In winter 2007 the author was invited to Beijing to give a long lecture to a selected audience of medical elite of China. In Q&A session a high officer of Chinese ‘FDA’ stood up, praised the lecturer for finally explaining to him what cell transplantation is all about. Then he followed: ‘You came just in time. Our government has decided to ban stem cell transplantation. Reason? They were exhausted by having to dealwith one continuous string of scandals.’ Subsequently several hospitals and clinics heavily promoting stem cell transplantation in the West were closed down. But the ban of stem cell transplantation in China did not take place. Later on the author proposed to the leader of the Chinese group, a retired big general, well known from history textbooks, to organize the preparation of cell transplants by BCRO method in China. The answer was: ‘No! Our elite would never allow an implantation in their bodies of any cells prepared in China, even though you would supervise it. You just keep on preparing cell transplants in Europe and deliver them to China by a currier.’ In 2007 a similar proposal made to governmental VIP’s in Indonesia was turned down, for the same reason.

5/ Beware of fancy, professionally perfect looking web sites marketing stem cell transplantation. Read the text in detail and compare it with the copy of this short web site. If you wish to study the issues in depth you may decide to consult the textbook for physicians “Fetal Precursor Cell Transplantation, BCRO Fetal Precursor Cell Transplantation” by E. Michael Molnar, M.D., posted as a new edition on amazon.com in January 2015.[1]

6/ If you decide to consult your own physician, make sure that you are asking a professional that actually knows something about stem cell transplantation. Many physicians like to ‘play god’ and wrongly advise their patients about subjects they know nothing about!

7/ Further on in the 'Summary of Scientific Facts' you will learn thatembryonic stem cells are unusable for an actual patient treatment – due to their cancerogenicity - the fact that has been known in Europe and USSR/Russia for several decades’. It already happened in U.S.

8/ Further on in the 'Summary of Scientific Facts' you will learn that ‘fetal precursor stem cells of animal fetal origin are equally effective, and safer, for the patient treatment as those of human fetal origin, so that all difficulties with human fetal stem cells can be avoided’. Why safer? By U.S. law all animals used for preparation of fetal cell transplants must originate from ‘closed colony’. In case of rabbits the minimum period that a community of rabbits must live together in closed colony, separated from the rest of the world, is 30 generations, i.e. a minimum of 3 years under constant detailed veterinary observation before their fetuses could be used for preparation of animal fetal precursor stem cell transplants. Could human beings be kept under such observation before using their fetuses for the preparation of human fetal precursor cell transplantation?

Next: After euthanasia is carried out in accordance with the established rules of laboratory medicine the uterus with fetuses from the rabbit female is taken out and immediately passed to the sterile laboratory where all fetuses and placentas are removed from the amniotic sac without delay. After the veterinary pathologist found at autopsy that all organs and tissues of each fetus were normal, all organs and tissues necessary for preparation of all fetal precursor stem cell transplants for the treatment of a specific named patient are collected, all the while the heart is still pumping, blood is pink, fully oxygenated. To get the human fetal cell transplants one must wait for the natural or induced birth of the second trimester fetuses, necessary for preparation of human fetal precursor cell transplants, which takes hours, so that the fetus has not been receiving oxygen for a long time, and thereby the condition of organs and tissues to be planted onto the primary tissue culture is incomparably worse as those from animal fetus. As a result, the quality of human fetal cells cannot ever match that of animal fetal precursor cells.

‘Closed colony’ is described in the educational booklet of the World Health

Organization, as well as in the textbook of E. Michael Molnar, M.D. There is no ‘closed colony’ of rabbits in U.S., but there are 11 in Europe.

9/ Beware that umbilical cord blood, or peripheral blood, contain only stem cells of hematopoietic and immune systems, as well as a very limited quantity of stem cells of mesenchyme, rather than fetal cells of 200 – 220 cell types that our body and bodies of all mammals are built from. For that reason diseases of central nervous system, digestive system, urinary system, respiratory system, genetic and chromosomal diseases, etc. cannot be treated by the umbilical cord blood cell transplants, or by peripheral blood cell transplantation! Umbilical cord blood of human newborn contains hematopoietic and mesenchymal stem cells only, but not ‘Universal Cells’. It is due to the fact that anglophone ‘peer reviewed journals’ still avoid acceptance of the ‘principle of organospecificity’ that all the fraudsters marketing umbilical cord blood cell transplantation, adult autologous ‘stem’ cell transplantation, implantation of ‘stem cells’ from fatty tissue, can lie to the public that they are implanting non-existent ‘universal stem cells’, ‘Mother-of-all-Cells’, etc.

The medical malpractice, i.e. use of umbilical cord blood cell transplantation for treatment of diseases where there is not even a theoretical chance to help the patient has been happening daily.

BCRO clinical method of fetal cell transplantation based on the German school requires that the treatment be individualized' by 'tailoring' the combination of stem cell transplants to the pathophysiology of specific disease(s) of a specific named patient, all that on a cytological level, that no physician to-date was taught in medical school and that has always been based on the principle of organospecificity.'

In 2007 – 2009 the author was invited several times to southern India to give all day long seminars and lectures to physicians of many medical schools, governmental medical research institutes, hospitals of Apollo Group Hospital Corporation, as well as to give BCRO FCT treatment to several colleagues suffering from incurable and untreatable diseases.

A 42 years old male physician requested a consultation. He suffered from genetic neurodegenerative disease that his mother and older brother died from already. Trying to save his life he received umbilical cord blood cell transplantation at the best hospital in India known for such treatment. He was assured by his treating physicians that such stem cell transplantation will help him. When his condition was getting worse rather than better he kept coming back to his colleagues for follow-up visits and continued to be re-assured that he will be fine. When the author consulted him 18 months later he was in the pre- terminal state. There was no way to continue to lie to him about the fact that umbilical cord blood cell transplantation could not possibly cure or alleviate his illness the way his Indian colleagues did. The author advised the patient/colleague that BCRO type of fetal cell transplantation would stop further progression of his illness but that would mean just continuous life of suffering, with patient unable to swallow saliva and gasping for each breath. The colleague/patient did not request BCRO type of fetal cell transplantation.

10/ Even more serious fraud warning must be issued about the adult autologous stem cell transplantation.

Stem cell auto-transplantation, i.e. therapeutic use of a patient’s own stem cells, tissues, etc., has been introduced into clinical practice only recently. Adult autologous stem cell transplantation has been popularized by media as ‘miraculous treatment’ for one simple reason: as it is a re-implantation of patient’s own cells the regulatory organs worldwide have no right to interfere. Besides that no immune response will take place after auto- transplantation. Adult organism contains necessary quantity of stem cells without which the regeneration and continuation of life would not be possible. The problem with this therapeutic method has been its limited usefulness and minimal effectiveness. Beware that adult autologous stem cells are as old as the patient is, and thereby their biological potential is limited. So if you are 64 years old, your stem cells are also 64 years old. Their therapeutic effectiveness is incomparably lower than of stem cells of a fetus less than 0 years old. Stem cells obtained from the fetus are much more numerous than rare adult stem cells, and they possess certain unique properties, such as: - high level of readiness to differentiate and undergo changes in response to environmental stimuli, or in accordance with their own genetic make-up; - easy adaptability, due to the plasticity of tissues (including growth, migration, mobility, ability to create cell-to-cell contacts),that in the course of normal fetal development gradually decreases, and finally disappears at the completion of development; - much more frequent and faster cell division, and proliferation, as compared with adult stem cells, depending upon the type of tissue and stage of fetal development; - production of large amounts of various biological substances, i.e. growth factors, etc., which facilitate the survival and growth of stem cells after implantation, and stimulate damaged cells, tissues and organs of the host; - lowered immunogenicity, with a consequently much weaker immune response of the host, as compared with an implantation of adult cells or tissues - ability to survive on energy supplied by glycolysis alone, and thus on lesser amount of oxygen, which is important during the preparation of stem cell transplants, and during the first hours after implantation; - lack of cell extensions easily damaged during processing of cell transplants. The clinical effectiveness of fetal cells is incomparably higher than of adult stem cell auto-transplants.

Adult autologous (stem) cell transplantation is absolutely not a source of ‘universal stem cells’.

Another problem is that source of adult stem cell auto-transplants are the patient’s own tissues. There are only ~ ten types of cells that one can obtain from patient’s own body with relative ease. It is simple to get blood, skin, connective tissue, fatty tissue, peripheral muscle tissue. To get some other cell types requires a traumatic procedure of needle biopsy, with possible complications: liver, kidney, spleen, thyroid, while for others endoscopy, laparoscopy, excisional biopsy of various magnitude, or larger invasive procedure, etc. Only female patients can get mesenchyme and placenta at the end of pregnancy. Many cell types, such as those of central nervous system, pituitary, pineal gland, testis, etc. cannot be obtained at all.

In 2009 the author was invited to a private dinner by his two patients in their house. The hosts invited a Ph.D. pharmacologist who became very wealthy after the sale of his patent to the pharmaceutical industry. He became an owner of an adult autologous stem cell transplantation clinic in Germany. The master of the house arranged a one-on-one conversation between the inventor/clinic owner and an author of this text. The inventor disclosed that he has been a patient in his own clinic. The author asked him about his evaluation of the results of his own adult autologous stem cell transplantation. The first treatment gave no positive result whatsoever. So the medical director of his clinic carried out the second treatment, again with no positive result. Then the inventor/clinic owner had the third treatment. This time there was a miniscule positive effect. The author asked the inventor/clinic owner why he kept on repeating the adult autologous stem cell transplantation when there was no positive effect. He continued useless treatment because the medical director of his own clinic told him that it is necessary to repeat adult autologous stem cell transplantation five times before the therapeutic effect becomes apparent. At this point the author interrupted the conversation to avoid a social embarrassment. Due to its minimal effectiveness the use of adult autologous stem cell transplantation for treatment of serious incurable or untreatable diseases is an outright fraud.

11/ The major fraud of late is the use of fat obtained during liposuction as a source of stem cells. All fat suctioned off during liposuction is processed by an equipment over the next two hours whereupon the processed fat, now called ‘stem cells’, is re-injected all over the body to correct body contour deformities. Between 2007 and 2009 the author was invited three times to Taiwan to conduct all day long seminars about fetal cell transplantation. In 2008 during one such seminar at the medical school in Taipei, he was asked if he would object when a colleague from Seoul, S. Korea, would during a lunch break speak briefly about a new method of stem cell transplantation. There was no objection. The colleague was a plastic surgeon. Once the author learned about this kind fraud he left the auditorium in silent protest. Now this fraud has spread from S. Korea throughout the world.

12/ You read a lot about patient’s own blood cells turned by various laboratory procedures into neurons, etc., but therapeutic effect of such hybrids have never been shown in human therapy.

In 2008 the author was invited to participate in a three-day round table discussion about SCT at the Middle Eastern Center of World Health Organization in Cairo, Egypt, organized by the Islamic Organization for Medical Science and World Health Organization. Another invited participant, Prof.Dr. W. Hurlbut, U.S. colleague, from Stanford University Medical School, an expert on the nuclear transfer in human embryonic stem cell transplantation, replied to the question from the audience about a recently published paper reporting on the use of skin from prepuce of a penis as a source for many different kinds of stem cells, including that of neurons, in a wonderful manner: “You can do all kind of ‘hokus-pokus’ in the laboratory, including changing the appearance of stem cell of one cell type into a stem cell of another cell type. But no one will ever state what happened when he tried to use such unnaturally obtained stem cell for stem cell transplantation to see if it works, i.e. helps the patient.”One can get very easily stem cells of all ~200 – 220 cell types human body and bodies of all mammals are made off, what is the point to go against Nature and God by forcing the cells to become what they were not meant to be.

On the other side the media campaign helped the worldwide recognition of stem cell transplantation by public, and some physicians, as therapeutically very valuable, particularly for those diseases with currently no known therapy, or where the ‘state-of-art’ treatment lost effectiveness. It took only a century since the first patients were so treated in western Europe, or 85+ years since its official declaration in Switzerland as a new item in physician’s therapeutic armamentarium, or 90+ years from its introduction into USSR medicine.

Medical publications by newcomers to this field fail to acknowledge that during the past 85+ years an ample research has been undertaken, enormous clinical experience gained by fetal cell transplantation treatment of over 5 million patients in Germany alone, (and 20+ million patints treated by implantation o cytotrophoblastic cell of placenta) and thousands of papers published in ‘peer-reviewed journals’ of countries where this treatment originated. Medical progress has always been based on the past discoveries, as the structure and function of human body have not changed for thousands of years and will not change for many thousands of years ahead of us. (Claude Bernard, world famous physiologist, in his article in the Bulletin Of New York Academy of Medicine, in 1929, page 997: “Man can learn nothing unless he proceeds from the known to unknown.) Contrary to this principle, all that has been learned about cell transplantation, and reported in medical journals and meetings over the past 100 years, is ignored today like in the Middle Ages when due to the same attitude the progress of medicine was set back for centuries. Regretfully, pharmaceutical industry has not found a way make profit in cell transplantation. BCRO approached in 1991 via our Swiss Representative Hoffman-LaRoche in Basel, Switzerland, about a cooperation, but there was no interest. In 1998 Sandoz Inc., later on merged with Ciba-Geigy into Novartis, paid for a financial study by Salomon Brothers “Unknown Potential of Xenotransplantation”, that contained a small chapter on cell and tissue xenotransplantation. We discussed a cooperation with Sandoz management with negative outcome since 25% of their income was from Sandimmun (Cyclosporin) and our method of cell transplantation did not require immunosuppression. Human embryonic stem cell transplantation is spoken about incessantly in the recent English medical literature, even though there is no ‘Mother-of-All- Cells’, or ‘Universal Cell’, from which allegedly are made any & all of ~ 200 - 220 types of cells making up the body of any member of animal kingdom, including ‘Homo Sapiens’. Human or animal bodies are created by union of sperm and ovum, not by a cell line of one embryonic stem cell propagated in the laboratory dish. Only cancerous growth is created that way. Although U.S. FDA issued guidelines for cell, tissue and organ, xenotransplantation in 2001, and the same guidelines are by a decision of U.S. FDA currently applicable to human embryonic stem cell transplantation as well, for unknown reasons U.S. medical science has ostracized cell and tissue xenotransplantation, and U.S. medical schools are focusing on human umbilical cord blood cell transplantation only. U.S. researchers spend all their energy and enormous sums on proving that hematopoietic stem cells can become neurons, pancreatic islets cells, basically any & all cells of the body, when it would be so much easier just to use the respective fetal cell xeno- transplants, with proofs of effectiveness obtained decades ago, and an enormous clinical experience accumulated.

You may get confused when terms ‘stem cell transplantation’ and ‘fetal cell transplantation’ are used side by side in this writing. The term ‘stem cell transplantation’ has been favored by a group of recent newcomers to this field versed in laboratory techniques but not in clinical practice of cell transplantation. Experienced practitioners of cell transplantation recognized decades ago that cell transplants of various organs or tissues contain all generations of the family of a certain cell type, including those of the precursor stem cells.

BCRO method of stem cell transplantation is not a ‘magic bullet’ either, i.e. a treatment of all known diseases.

At the same time, all patients with diseases with no known treatment, e.g. genetic or chromosomal diseases, or perinatal brain injuries, should be treated with fetal cell transplantation immediately after the diagnosis was made as time is of essence. Stem cell xenotransplants prepared by a BCRO method are safer than baby aspirin, and our experience has proven that there is no harm by trying to treat newborn and infants born with rare diseases, and not be preoccupied by a lack of medical reports or even an exact diagnosis.

There is no competition between ‘standard’ treatment of a disease as published in a U.S. ‘peer-reviewed’ medical journal and fetal cell transplantation. For example, type 1 diabetics must be treated by insulin alone until they develop complications; at that time fetal cell transplantation has to be added, as insulin alone cannot control the progression of retinopathy, nephropathy, peripheral arterial disease, etc., toward blindness, kidney failure, gangrene, impotence, etc. This was declared in 1930 by Alexis Carrel, U.S. Nobel Prize winner.

Fetal cell transplantation was developed primarily by brilliant clinicians responding to a challenge by patients advised by their physicians that the standard medicine had nothing to offer as a treatment of their illness(es).

Many problems associated with the use of human embryonic and fetal cells in medicine have been easily resolved by using cell transplantation of animal fetal origin to help patients suffering from deadly incurable, or untreatable, diseases. Therapeutic use of fetal cell transplantation of animal fetal origin in ~ 1 million patients over 90+ years has accumulated sufficient data to assure public that this treatment is not dangerous to an individual or to mankind.

The above number of 1 million patients represents over 99% of all patients that have received ‘real’ (stem) cell transplants to-date.

There are no incurable diseases only those that we do not know how to cure yet. Used properly the fetal precursor cell transplantation will lower the number of incurable or no longer treatable diseases.