Description of various fetal precursor cell transplants
LANGERHANS ISLETS OF PANCREAS: Organ culture, individual cells and cell clusters, islet cells with granules, estimated 80% of total B cells (ß), 10% A (alpha), D and PP cells, and 10% other cells, including fetal precursor cells.
ADRENAL CORTEX: Organ culture, 70% of total cells are of the fetal layer, which include fetal precursor cells, 20% of zona fasciculata, 10% of zona glomerularis (percentages estimated), cells round, polyhedral or pyramidal, without granules.
PITUITARY GLAND: Organ culture of anterior lobe of the gland, some cells are with granules (chromophils), others without (chromophobes). Occasional glial cells (’pituicytes’) can be found.
THYROID: Organ culture containing follicles with colloid, round or cubical cells, less than 5% of total are somewhat larger C cells with granules. Some parathyroid cells can be found: small chief cells with some granules and rare large oxyphil cells.
OVARY: Organ culture consisting predominately of follicular (’granulosa’) cells of the primordial follicle.
TESTIS: Organ culture consisting predominately of smaller interstitial Leydig cells, larger Sertoli cells and spermatogenic epithelium.
PROSTATE: Organ culture consisting largely of granular cells originating from seminal vesicles, tuboalveolar glandular structures, and some smooth muscle fibers.
STOMACH/INTESTINE: Organ culture, primarily consisting of cuboidal stem cells, round parietal cells and granular zymogenic cells of stomach, pancreatic stem cells, and of intestinal absorbtive cells with brush border, all originating in the mucosa, with a component of lymphoid cells.
LIVER: Organ culture, individual cells or cell clusters, 90% hepatocytes, the remainder consists of hepatic fetal and hematopoietic stem cells, endothelial cells and some Kupffer cells.
THYMUS: Organ culture consisting predominately of lymphocytes (T- and B-) and epithelial reticular stellate cells.
KIDNEY: Organ culture, primarily of the cortical layer, consisting of round podocytes, larger round to cuboidal cells of convoluted tubules, with and without brush border.
HEART MYOBLASTS: Organ culture, individual cells or cell clusters, fusiform cells with central nuclei.
MUSCLE MYOBLAST: Organ culture, individual cells or cell clusters, fusiform cells with peripheral nuclei, with some fetal precursor cells, a tendency toward syncytial arrangement.
SPLEEN: Organ culture, network of reticular tissue with lymphoid cell and macrophages, arranged in Billroth cords, with thoroughly washed off blood elements, some flattened sinusoidal endothelial cells.
LYMPH NODES: Organ culture, network of reticular cells with lymphoid cells and macrophages, partially arranged in medullary cords and sinuses.
LUNG: Organ culture, dispersed cell clusters of terminal and respiratory bronchioli and of alveolar system, estimated 30% of alveolar cells, 30% of endothelial cells, 30% of interstitial cells and 10% of macrophages.
PANCREAS: (Even at the fetal stage 85% of the mass of pancreas is that of an exocrine gland. This preparation fulfills that function.) Organ culture, typical serous cells with granules, some disassociated acinar arrangement, and centroacinar cells. Also cells of the Langerhans islets.
MESENCHYME: Abundant amorphous ground substance, mostly of hyaluronic acid, pluripotential fibroblasts.
PLACENTA: Organ culture, dispersed cytotrophoblast cells from both fetal and maternal portion, with a few chorionic villi, decidual cells, endothelial cells.
CARTILAGE: Organ culture, prepared from hyaline cartilage, with extracellular matrix with type II collagen, and chondroblasts, also of attached perichondrium with type I collagen and numerous fibroblasts.
BONE: Organ culture, prepared from cancellous portion of long bones, with multiple osteoblasts from endosteum, also with some haematopoietic stem cells of bone marrow.
HYPOTHALAMUS/THALAMUS: Organ culture, individual cells and cell clusters, of multipolar smaller neurons of the autonomous nervous system variety, with an abundance of glial cells.
BASAL GANGLIA: Organ culture, individual cells and cell clusters, of multipolar neurons and abundant glial cells.
CEREBELLUM: Organ culture, individual cells and cell clusters, consisting of Purkinje cells and very small neurons, with an abundance of glial cells.
CEREBRAL CORTEX: Organ culture, individual cells or cell clusters, consisting of a variety of neurons, including those of pyramidal shape, with an abundance of glial cells.
WHITE MATTER OF BRAIN: Organ culture, occasional small neurons, some of them fetal precursor cells, more glial cells, fragments of axons.
BRAIN STEM: Organ culture, individual cells or cell clusters, consisting of a variety of neurons, usually of smaller size and abundant glial cells.
CEREBRUM: Organ culture, individual cells or cell clusters, consisting of a great variety of neurons, some of them fetal precursor cells, with abundant glial cells.
PINEAL GLAND, Organ culture, individual cells or cell clusters, consisting of melatonin producing pinealocytes and astrocytes.
Fetal precursor cell transplants of any of the 200 types of cells could be theoretically made if we would know enough of them to be useful for treatment of any disease. Today only 90 cell types are actually made for treatment so they are prepared in our laboratory.
Besides that artificial organs with a bio-polymer base and any of the fetal precursor cell -transplants can be prepared. The same applies to biologically enhanced bio-degradable bio-polymer materials for reconstructive surgery, such as bio-degradable biopolymers used together with an osteogenetic combination of fetal precursor cell xenotransplants, foam hydrogel used together with a chondrogenetic combination of fetal precursor cell xenotransplants, foam hydrogel used together with a soft tissue combination of fetal precursor cell xenotransplants.