Autism

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Kanner described in 1943 ‘early infantile autism’, an abnormal behavioral pattern in early childhood, with onset from birth to 30 months of age, with five typical clinical features:

1/ profound lack of affective contact and social interaction with other people;

2/ repetitive, ritualistic , symbolic behavior, that must be of an elaborate kind, with obsessive desire for the preservation of sameness, i.e. routine acts and environment must be maintained to the most minute detail; as well as

3/ fascination for objects that are handled with unusual motor skills;

4/ mutism, or a kind of language that does not lead to normal inter-personal communication;

5/ even though the intellectual performance is sub-standard down to the level of mental retardation, cognitive potential is excellent as shown in memory features, or during performance tests.


U.S. incidence was 1/10,000 in 1943, today it is 1/100, i.e. much higher than for Down syndrome.


The cause is still unknown, theories range from childhood schizophrenia, to ‘bad parenting’, to genetic factors, or biologic factors that evolved during development, e.g. heavy metal toxicity causing an inhibition of cell migration and thereby delay of brain development, and recently also a theory of autoimmune ‘neuro-immunological’ damage. French company IntegraGen identified 12 genes associated with autism..

Immunisation by MMR (measles, mumps, rubella) has been identified as a major etiological factor, although some believe that the actual noxious factor has been Thimerosal used as a preservative, but the fact that both measles and mumps components of the vaccine consist of live attenuated viruses cannot be dismissed.

Exposure to chemicals, such as paints, pesticides, new furniture or carpets, or on the job, i.e. heavy metals, during the pregnancy, has been found in many mothers of autistic children.

‘Leaky gut syndrome’, i.e. inappropriate permeability of the intestinal wall leading to an excess absorption of microbial toxins, or allergenic or toxic breakdown products of food proteins, and faulty liver detoxification of toxic substances, are responsible for a toxic overload of the developing body.

Autistic children have larger heads. This is due to an enlargement of the mass of both grey and white matter of frontal lobe between 2 and 5 years of age, that becomes normal later in life, but then dorsolateral pre-frontal cortex and medial frontal cortex, areas important for language, social abilities, but not motor cortex, grow excessively in size. Finally, the grey matter of amygdalae, important for processing of emotions, is 20 % larger from 7 to 12 years of age, but not later in life.

The illness develops insidiously in toddlers after a normal infancy without any evidence of developmental abnormalities or hallmarks of severe mental retardation or cerebral palsy. At around 18 – 24 months of age it is obvious that previously normal developmental milestones are no longer attained. Normal communication between parents and a child gradually disappears. Autistic child does not make eye contact, and the speech, is rudimentary. There is a prolonged repetitive behavior, and a lack of normal subtle emotional expressions.


Fetal precursor cell transplantation has been exceptionally successful for the treatment of classical autism, i.e. early infantile autism, childhood autism, or Kanner’s autism. The same statement does not apply to any other 7 disease conditions listed under "autism spectrum disorders" that have nothing in common with the classical 'Kanner' autism/

In December 2006 the professor of internal medicine in Hong Kong asked the author to give a consultation to parents of 9 years old autistic boy as a professional courtesy because he knew that the author was refusing requests to treat authistic patients with BCRO method of fetal precursor cell transplantation, because he was influenced by unanimous opinion of medical profession in California that autism is a psychiatric disease and as such untreatable by cell transplantation.. The parents were highly educated young people and thereby highly qualified to carry out the worldwide search for any information about autism who in 2 ½ hours long lecture convinced the author that BCRO fetal precursor cell transplantation treatment should not be denied to their son.


The author remembered, of course, all that he learned in medical school about the extensive research that European military medicine carried out in preparation for WW2 when a decision was reached that all young men drafted for the military service who have not had measles as children had to get an immunization against measles despite the risk of ‘porencephalitis' which was unavoidable since the vaccine had to be ‘live attenuated’.


This patient who in December 2006 had to be handled by three able bodied men to prevent him from destroiyng the doctor’s office, acted now - two months after BCRO fetal cell transplantation - like a perfect gentleman, looking the author straight in the eyes, shaking his hand, and giving him a kiss on both cheeks. In the patient’s private school where no one knew about the treatment by BCRO fetal precursor cell transplantation , all teaching staff was unanimously talking about a ‘miracle’ taking place.


The spectacular result of BCRO fetal precursor cell transplantation carried by the author in February 2007, observed by him two months later, convinced all present that fetal precursor cell transplantation should not be denied to patients with classical Kanner autism.


Based on the well known fact that the implanted BCRO fetal precursor cell transplants of a certain organ or tissue will ‘home’ only to the organ or tissue of the SAME origin that is DAMAGED(!) by the disease, injury, or faulty growth and development,

and repair that same damaged organ or tissue, but NOT the SAME organ or tissue if NOT DAMAGED, the dramatic improvement of the autistic condition of the patient proved the point that autism is due to ‘organic damage of the brain’ and not due to a psychiatric disease.

Besides that the fact that just one implantation of fetal precursor cell transplants improves all symptoms of autism beyond any doubt of parents or any other observer.

In autism there is one (or more) tiny inflammatory foci of ‘por-encephalitis’ in the brain, too small to be identified even by the today’s finest super modern diagnostic methods. BCRO type of fetal precursor cell transplantation stops the pathologic electric discharges of the ‘por-encephalitic focus’ in the brain, thereby allowing healing process to proceed. 

After healing the re-education process to learn all the knowledge and life experience that the autistic patient could not acquire in school, and lost in,can begin.

Parents and close observers recognize with ease that continuous intake of psychotropic drugs cannot accomplish that.


Altogether 18 autistic children were treated by BCRO fetal precursor cell transplantation in 2007, 14 of them adequately documented. Of these 14 patients only one, nearly 13 years old at the time of treatment, showed no response to BCRO fetal precursor cell transplantation treatment. In all others the response was positive, actually highly positive.


Investigation of the treatment failure in 13 years old boy clearly pointed out that the closure of the blood-brain barrier that apparently takes place at the average age of 12 was the cause. From then on all patients 11 years old or older received the BCRO fetal precursor cell transplantation intrathecally (via lumbar puncture) with a complete success. The oldest patient successfully treated by fetal precursor cell transplantation carried out intrathecally was 24 years old male from Singapore.


Lately a new classification of ‘autism spectrum disorders’ was developed that includes

Rett’s disorder. Childhood disintegrative disorder, Pervasive developmental disorder, not otherwise specified (PDD-NOS), and Asperger disorder, as well as patients with Attention deficit disorders (ADD) and Attention deficit hyperactivity disorder (ADHD). The last two are not medical diagnoses whatsoever but conditions caused by bad teaching, thereby substantially confusing the matters. Very few pediatricians and pediatric neurologists were capable to assuredly diagnose true Kanner autism and even lesser number of them have been able to diagnose various ‘autism spectrum disorders’.


There is insufficient experience with treatment of children with ‘autism variants’ so that only those with true Kanner autism should be accepted for treatment by fetal precursor stem cell transplantation. The author treated by fetal precursor cell transplantation one patient with Asperger syndrome and refused all patients with Attention deficit disorder as well as Attention deficit hyperactivity disorder.


Fetal precursor cell transplantation has to be given immediately after the diagnosis of true autism was made. While in the state of autism such a patient loses contact with the world, with subsequent loss of mental development, speech, education, learning of social skills, etc. The longer the patient remains in the autistic condition, the longer it will take for the patient to reach the normal milestones. Since autism is apparent by the age of 2, maximum of 3, years of age, fetal precursor cell transplantation should be done – at the latest – before attaining 4 years of age. Human brain is the sole organ which continues its fetal development after birth, its maturation and differentiation! This makes central nervous system very vulnerable to noxious stimuli but offers unique therapeutic possibilities. This ‘therapeutic window’ of the first 3, maximum 4, years of life, must be taken advantage of, as wasting this opportunity means losing vitally important therapeutic chances forever!

Some patients with unclear diagnosis of true autism , labeled as ‘ developmental delay’, etc. should not be automatically refused the treatment since patients with ‘developmental delay’ have been successfully treated by fetal precursor cell transplantation.


There is no other effective treatment for the damage of central nervous system, genetic disorders, autoimmune diseases, ‘leaky gut syndrome’, liver malfunction, but fetal precursor cell transplantation, as observed in clinical practice when treating infants and small children suffering from the inborn disease of the above systems.


Rimland pioneered therapies that are successful to some degree in autistic children, based on mostly dietary changes and use of nutritional supplements. Elimination from the diet of sugar, gluten and casein, and of artificial ingredients (additives, coloring), along with dietary supplementation of essential fatty acids, aminoacids tryptophan, tyrosine, and taurine, vitamin B6 and magnesium, with addition of dimethylglycine, improved the condition of many autistic children. Antioxidants, and acidophilus, are important components of healthy diet of an autistic child. Chelation therapy is available for heavy metal poisoning as one of the recognized pathogenetic mechanisms.


Standard therapies of applied behavior analysis (ABA), verbal behavior therapy, speech & language therapy, occupational therapy, music therapy, sensory integration, auditory training, have been used for autistic patients, occasionally with success.



Clinical protocol for treatment of autistic patients by BCRO fetal precursor cell transplantation


1/ A cause of true autism is a minimum organic brain damage, i.e. ‘porencephalitis’, as discovered before WW2.

2/ Each patient must have a test for chronic heavy metal poisoning by hair analysis. If the results are grossly abnormal then a chelation therapy has to be carried out. Fetal precursor cell transplantation must not be started until the level of heavy metals has not returned to normal, or as close to it, as possible.

3/ Fetal precursor cell transplantation does not have to be repeated. Such treatment should begin preferably prior to 4 years of age. BCRO fetal precursor cell transplantation past 11 years of age must be carried out intrathecally via lumbar puncture.

4/ Treatment is a complex one, besides fetal precursor cell transplantation it includes non-specific and specific metabolic stimulation, i.e. gluten-free and milk-free diet, appropriate doses of vitamin B6 and glycine, and all appropriate rehabilitation measures, special education, etc..