Aging Disease

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If medical textbooks include such topic at all, aging is declared a natural process, there is no ‘aging disease’, and there is no reason for any R&D as there is nothing that you can do about aging anyway.

World Health Organization Study Group on Aging and Working Capacity met in Helsinki, Finland, in 1991, and analyzed all issues thoroughly, i.e. demographics, aging workforce, ratio of retired people to the working population, physiological changes with age, age and work performance, mortality, morbidity, disability, and advised governments on problems in this area, but no time whatsoever was devoted to discussion how to influence aging by therapeutic means. The message to the aging population world over was clear: the very moment you stop working you are becoming a financial burden on governments, so why to talk about any therapies for the aging-related diseases that would require even more funds.


But 80% of 5 million patients treated by fetal cell transplantation / zellentherapie worldwide during the last 85 years have done so because they suffered from 'aging disease'. Their decision was based on their instincts and intuition, and in total disregard of official statements about a lack of acceptable research protocols to prove the value of any therapy in slowing down the aging process. Medical profession may ridicule it, but many of their patients wish to do something about it: not to add years to life, but life to years.


The percentage of older people is growing and not only in ‘highly developed’ countries, but also in those labeled as ‘developing’. In our life, after a developmental phase, or a period of maturation, and a period of maturity, comes inevitably a period of regression. Motor, psychological/social, and intellectual skills are acquired during the developmental phase, utilized during maturity, and then gradually lost during the regression period: abilities acquired last are lost first.


The goal of medicine should be not only to find out why aging takes place, but also discovering therapeutic and other means to preserve the vitality of aging organism for as many years to come as possible, and perhaps until the limit of our life, that is according to scientists 120 years.


The causes of aging disease are hypothetical because it is impossible to run a longitudinal study on vitality in man. Framingham study ran for 20 years but that is not long enough for study on vitality and aging. Many healthy controls have to be found to establish a baseline of ‘healthy aging’ and they are largely not available. There is a considerable variation in the lifestyle of controls, thereby limiting accuracy of the ‘baseline healthy aging parameters’. Our empirical knowledge, based on the treatment of millions of patients spread over 85 years, compensates greatly for this deficiency of science.


Vitality measures an ability of one’s organism to realize all vital functions in physical, mental and spiritual spheres. It is an optimal performance of capacities existing in an individual. ‘Devitalization’ means a loss of vitality due to aging disease, and other diseases. ‘Revitalization’ means a re-establishment of lost functions, while ‘rejuvenation’ goes beyond that limit, as it means improvements in one’s total biological capabilities, or lowering of one’s biological age. Some are critical of the term ‘rejuvenation’ but the author met people, who accomplished that. It requires a complex therapeutic approach, i.e. more than fetal precursor cell transplantation, and a belief that it can be done.


Biological age refers to functional capacities of an organism corresponding to the respective stage of individual’s lifespan. There were several attempts to develop a system of assessment of biological age simple enough to be useful in everyday clinical practice, such as that of E. Ries, that includes an evaluation of * * cardiovascular system, i.e. blood pressure, vital lung capacity, partial pressure of arterial oxygen, Ruffier functional index,

  • sense organs, and psyche, i.e. visual acuity, audiogram, color-word-test by Stroop, reading ability, speed of movement,
  • locomotor system, i.e. power of hand muscles, hand dynamometer, tendon extension in degrees,
  • dental status, i.e. number of decayed, missing and filled teeth. [254]


What are the leading symptoms of ‘devitalization’?

  • lack of initiative,
  • lack of activity,
  • rapid exhaustion,
  • reduced physical capabilities,
  • reduced psychological responses,
  • reduced alcohol tolerance,
  • loss of ambition,
  • reduced self-confidence,
  • dullness, despair,
  • lack of concentration,
  • impaired memory,
  • insomnia,
  • depression.


For the sake of an early diagnosis, and ability to evaluate the results of therapy, a more detailed lists of ‘devitalization’ symptoms & signs’ were devised, such as the one of F. Schmid.


‘Personality’:

loss of initiative,

lack of vigor,

emotional ‘emptiness’,

lack of inspirations,

feeling of insecurity,

egocentric behavior,

inability to act,

loss of sanity;


Gross motor abilities’:

rigid posture,

unsteady gait,

shuffling walk,

reduced walking distance,

difficulties to climb stairs,

walking with walking aids;


‘Fine motor abilities / Coordination’:

reduced mimicry,

reduced gestures,

tremor,

shakiness,

unsteady grip,

restlessness;


‘Social behavior / Psyche’:

discontent,

self-reproach,

loss of interpersonal relationships,

fear of living,

desire to live like a hermit,

loss of interest in sports,

politics,

acquaintances,

environment,

hobbies;


‘Intellectual performance’:

impaired comprehension,

impaired intellectual grasp,

memory disturbances,

loss of short-term memory,

‘senseless’ mistakes,

reduced concentration,

reduced vocabulary,

loss of contemplation,

taciturnity,

monotonous stereotypes,

loss of orientation abilities;


‘Physical regression’:

skin atrophy,

vascular sclerosis,

cerebral sclerosis,

aged heart,

pulmonary emphysema,

digestive disorders,

impotence,

menopause,

old-age diabetes,

liver disorder,

immune deficiency.


A physician cannot treat aging related diseases, or for that matter many other diseases in an aging individual, without an anti-aging treatment. On the other side, one cannot seriously talk about the 'revitalization' therapies, or a treatment of aging disease, without a ‘state-of-art’ diagnosis of any and all diseases that the patient suffers from, and their successful treatment, because otherwise any attempt at 'revitalization' will fail. 


There are not too many 40+ years old individuals in the western world today that are perfectly healthy physically, mentally and spiritually, and thus does not require treatment of 'aging disease'. The earlier in life the revitalization program is begun, the better are the results. The best time to start is between 40 and 50 years of age. The later the revitalization program commences, the more aggressive has to be the therapeutic approach , i.e. various simultaneous therapies, and in shorter time intervals.


Gianoli reports on the treatment of 531 own patients by cell transplantation with a success rate of 75% . The therapeutic effect lasted 8 – 12 months, and never more than 24 months. [258]


The Merck Manual of Geriatrics [242] defines the usual aging as 'changes due to the combined effects of the aging process and of disease and adverse environmental and lifestyle factors', while successful aging as 'changes due solely to the aging process, uncomplicated by damage from environment, lifestyle, or disease'.  These excellent definitions that acknowledge the possibility of 'aging successfully' stem from the growing acceptance of the rights of the aging population to live a full and complete life rather than to die in a hurry right after the retirement.


In reality the 'usual aging' should be classified as an ’aging disease’, and all diseases related to aging should be clearly described as such. Scientists agree that genetically we are programmed to live 120 years. In reality we live on average less than 80 years in the civilized world. But there are some societies with simple lifestyle where people live frequently much longer than that. 


The ‘succesful aging process’, that should lead to our graceful demise at the age of 120 years, is disrupted in principle by three factors: severe illness, severe trauma, or ‘usual aging’, i.e. 'aging disease'. The first two factors are self-explanatory: severe disease or severe trauma can destroy even the healthiest individual. But what about the 'aging disease'? Here are some well established facts:


1/ The rate of age-related decline in the function of every organ in the body varies greatly, so that people become less alike as they age; 

2/ Within any organism the functions of different organs decline at different rates;

3/ Each one of us has at least one weak organ or organ system;

4/ Different people age at different rates.


There are two major types of 'aging diseases': those that are accidental or random, and those that are programmed.  We seem to age 'by accident’ and ‘by design': it is not only that the stresses and strains and traumas of everyday life set off processes which make us grow old, there is some internal mechanism limits our lifespan. Our evolutionary, biological, purpose is fulfilled once we have passed on our genes, and have protected our children until they can protect themselves. Once that happened, around the age of 40, we begin to notice the aging process.


Before that time our bodies have been in a state of dynamic equilibrium, constantly renewing, rebuilding, and replacing every cell in the body by cells of equal quality. Now our physiological functions begin to decline. Our ability to adapt to, and survive in a changing environment, declines. All over the body, the structure of tissues becomes disorganized. 


More fat is deposited. Numbers of key cells of each organ or tissue decrease. Individual cells increase in size, but diminish in number, by almost one-third. Connective tissue between cells, muscle fibers, and bones enlarges and becomes less elastic.


Myocardium and the heart valves lose gradually their elasticity and strength, although the left ventricular wall thickens as a result of myocardial hypertrophy and increased quantity of fibrous tissue. 


As the heart grows weaker, the blood vessels become more rigid due to changes in the amount and nature of elastin and collagen in their walls, and calcium deposits, as well as clogged with fatty atheromas of atherosclerosis. Blood pressure rises.


In the kidneys, the number of functioning nephrons decreases 30 - 40 % between ages 25 and 85, with the related loss of renal mass, particularly of the cortical layer. This leads to a reduced renal blood flow, glomerular filtration rate and performance of tubular system.


The vital capacity of the lungs decreases, while the residual volume increases. The gas distribution irregularities and decreased compliance of the lungs cause lowered arterial oxygen tension. The diameter of chest wall increases, and the flexibility decreases. The maximum breathing capacity decreases steadily: in 80’s it is one half as compared with 30’s. From age of 55 on the respiratory muscles begin to weaken.


The motility of digestive system is affected by aging process first of all functions. This leads to constipation, incontinence and diverticulosis, which become a cause of many problems with digestion and absorption of nutrients. Production of all digestive enzymes declines. Liver weight, and its blood flow, decrease.


The skin wrinkles, sags, and grows less elastic and dry. Healing takes longer. The hair thins and turns gray. Nail growth slows down.


Loss of muscle cells and disorganization of muscle tissue cause a progressive reduction in muscle strength. Half of muscle mass and of maximum isometric contraction force is lost between ages of 30 and 75. Joints deteriorate. Bones become weaker as more minerals are lost than are replaced.


Blood flow to the brain is reduced. Lost nerve cells are mostly not replaced. Connections between nerve cells are substantially diminished. The gross motor and fine motor abilities and coordination deteriorate. Psychometrically, reaction time slows down, learning takes longer, memory fades, in particular the recent one. The social skills and intellectual abilities of young years slip away. There are changes of personality.


Vision deteriorates as the lens and other parts of the eye become less transparent. Vision dims as a result of decreased adaptation to low light and darkness. Senses of taste, touch, smell and hearing grow weaker.


Menopause appears in women, loss of sexual potency in men.


When it comes to the treatment of 'aging disease' the opinions vary. This is due to the lack of a single hypothesis able to explain all aspects of aging processes. According to the Merck Manual of Geriatrics [242] there are six such hypotheses.


Experts have always believed in a complex approach to the treatment of aging disease, i.e fetal precursor cell transplantation alone is not sufficient. It has to start with lifestyle adjustments, correct nutrition, regular active exercise, proper handling of stress along with spiritual immersion. Normalization of function of all organ systems has to be attained by all means of orthodox and alternative medicine, all the while the elimination of toxins should be foremost on the mind of treating professionals. Two most important parts of the complex therapeutic approach are fetal precursor cell transplantation for direct stimulation of regeneration and – along with electromagnetic therapy – for securing the optimum performance of regulatory systems of the body.


Female patients should receive as a minimum fetal precursor cell transplants of ovaries, placenta, adrenal cortex, hypothalamus, mesenchyme, spleen, while male patients cell transplants of testes, placenta, adrenal cortex, liver, hypothalamus, frontal lobe of brain. Other fetal precursor cell transplants, necessary for the treatment of any other disease(s) that the patient suffers from, which have a negative influence on aging disease, are added.


Gross motor disturbances require also fetal precursor cell transplants of brain cortex, medulla alba of brain, spinal cord, and * if rigid posture dominates, then also diencephalon, basal ganglia, * if insteady gait dominates, then also cerebellum.

Fine motor disturbances require also fetal precursor cell transplantation of thalamus, diencephalon, basal ganglia, cerebellum, and if decreased mimicry, and reduced gestures dominate then also temporal lobe of brain, and frontal lobe of brain in female patients.


Disturbed coordination requires also fetal precursor cell transplantation of thalamus, diencephalon, basal ganglia, cerebellum.


Reduced initiative requires also fetal precursor cell transplants of thalamus, hypothalamus, and frontal lobe of brain in female patients.


Memory loss requires also fetal precursor cell transplants of temporal lobe of brain, and frontal lobe of brain in female patients.


Reduced intellect requires also fetal precursor cell transplants of brain cortex, medulla alba of brain, thalamus.


Arteriosclerosis requires also fetal precursor cell transplants of placenta, artery, mesenchyme, while cerebral arteriosclerosis placenta, artery, medulla alba of brain.


Senile heart requires also fetal precursor cell transplants of placenta, artery.


Impaired liver function requires also fetal precursor cell transplants of stomach /intestine.


Gout requires also fetal precursor cell transplants of kidney.


Senile lungs require also fetal precursor cell transplants of lungs, mesenchyme.


Osteoarthrosis requires also fetal precursor cell transplants of cartilage, bone marrow, parathyroids, mesenchyme.


Immune deficiency requires also fetal precursor cell transplants of thymus, and spleen in male patients.

Remember that in adults all implantations of fetal cell transplants of nearly all parts of CNS requires intrathecal implantation via lumbar puncture.


N. Wolf specialized for decades in treatment of patients with brain atrophy due to aging by various modifications of timing and dosage of cell transplantation of placenta and frontal lobe of brain only, sometimes including hypothalamus. He repeated such implantations every 4 weeks for 3 to 6 months in a new patient until there was a definitive improvement in the clinical status, and then the patient received the same treatment one to four times a year. In those instances when the patient’ condition became worse, he re-started the initial treatment schedule of implantation of above fetal cell transplants every four weeks. [243] His results were minimal because of lack of intrathecal implantations.


Menopause is the most significant period of life for women since it is the time of the greatest vulnerability, physical, mental and spiritual. Many educated women postpone this period into their later years by hormone replacement therapy today. It can be accomplished, yet hormone replacement therapy cannot replace fetal precursor cell transplantation. The center of regulation of sexual glands is in diencephalon, close to the centers for autonomous nervous system regulation and the centers for a variety of psychic functions. These three centers work closely together, and influence each other. Amenorrhea due to prolonged stress is not a rare occurence, and the same applies to the premature menstrual bleeding due to fright, or to the psychic disturbances, or autonomous nervous system changes, due to disorders of the sex glands regulation system. On the other side it is possible to improve menopausal malfunctions through psychotherapy, or by sedatives of autonomous nervous system.


Already in 1957 Bernhard reported on his success in treatment of menopause by cell transplantation of diencephalon, anterior lobe of pituitary, ovary, and placenta, in 98 patients with a natural menopause, in 49 patients with premature menopause, and 27 patients with artificial menopause, and stressed that the effect of cell transplantation is not due to a hormone replacement.


Lehmacher treated 6 patients with artificial menopause after a complete hysterectomy, and bilateral total oophorectomy, with cell transplantation of ovary and placenta with 100% success rate. None of these patients showed any estrogen effect on vaginal mucosa smear because cell transplantation does not work by stimulating ovaries to produce estrogen and progesterone. These patients were an excellent example because they did not have ovaries for production of estrogen and progesterone.


A preliminary report describing findings in the first 11 patients of a double blind study that included 40 patients, one half of which received cell transplantation of diencephalon, anterior lobe of pituitary, placenta and ovary, while the second half a placebo, states that cell transplantation did significantly improve the difficulties of menopausal patient, although no changes of FSH or 17-ß-estradiol were observed, and cell transplants had no hormonal effect whatsoever. Cell transplants of diencephalon, anterior pituitary, ovary and placenta, balance out the autonomous nervous system regulatory circuits. [313]



Clinical protocol for treatment of patients with aging disease by fetal precursor cell transplantation


1/ A patient with ‘aging disease’ needs an improvement of biological functions in their entirety (i.e. ‘vitality’): physical, mental and spiritual. As an example, to attend to a physical fitness of a deeply senile patient without an improvement of the mental state is not a sound therapeutic goal;

2/ A follow-up requires measurement of described parameters but also an evaluation of the ‘vitality’, which is to some degree a matter of the personal judgment of the patient;

3/ The more advanced are the symptoms and signs of aging disease the more thoroughful must be the diagnosis of malfunctions of all organ systems and the more attentive the after-care;

4/ The regenerative ability of an organism is diminishing with age, thus the ‘aging disease’ should be treated early, and repeatedly. The older is the patient at the time of the first treatment, the more frequent should be the treatment, i.e. in 50 years’ old patients every 3 years, while in 70 years’ old every year. But, as long as there is some regeneration potential left, and the patient is not in the terminal stage of some disease(s), fetal precursor cell transplantation should not be refused;


A proper preparation of the patient for fetal precursor cell transplantation is mandatory. A patient has to be brought into as compensated metabolic state as possible by standard therapeutic means, i.e. to carry out fetal precursor cell transplantation while the patient is in the state of severe malnutrition, dehydration, depression, etc., is probably minimally effective and should be done only as a last resort.


Parameters to be followed in patients before and after fetal precursor cell transplantation, and the frequency:


Physical:

i/ complete blood count, urinalysis every month

ii/ creatinine clearance every 3months

iii/ serum alkaline phosphatase every 3months

iv/ serum cholesterol: total, LDL, HDL, and triglycerides every month

v/ fasting blood sugar every month

vi/ serum calcium and phosphorus every 3 months

vii/ blood pressure every month

viii/ exercise EKG testing every 3 months

ix/ spirometry every 3 months

x/ serum estrogen, progesterone or testosterone every 6 months

xi serum FSH and LH every 6 months

xii/ visual acuity every 6 months

xii/ audiogram every 6 months

xiii/ bone density every 6 months (females only, males only if indicated)


Immunological: once a month x 3, then every 3 months:

i/ total lymphocytes

ii/ T-lymphocytes (CD3+)

iii/ T-helpers (CD4+)

iv/ T-suppressors (CD8+) and CD4/CD8

v/ NK (CD16)

vi/ B-lymphocytes (CD22 and CD19)

vii/ serum IgG, IgA, IgM

viii/ serum complement (CH50)


Neuropsychological evaluation every 6 months or at least once a year:

i/ personality: loss of initiative, loss of drive, loss of affection, loss of imagination,

general insecurity, easy tiredness, unmotivated depression, despair, loneliness, egocentrism, inability to act, loss of ‘soundness of mind’, loss of attention span;

ii/ gross motor: impairment of posture, gait, and balance;

iii/ fine motor function and coordination: poverty of mimicry and gesticulation, tremor,

restlessness , impairment of grasping of objects;

iv/ social: sullenness, self-reproach/self-accusation, loss of interest in intersocial relations, loss of interest in politics, sport, friends, hobbies, surroundings, fear of life;

v/ intellect: impairment of comprehension of new ideas, impairment of thought, decrease of concentration, loss of thoughtfullness, monosyllabism, monotone stereotypes, loss of recent memory, decrease of vocabulary, loss of orientation ability, speech impairment, impairment of abstract thinking, impairment of judgment.


Various scales can be used as well, such as:

1/ Mini-Mental State Examination form (MMSE)

2/ Hamilton Depression Scale or Yesavage Geriatric Depression Scale

3/ Sandoz Clinical Assesment - Geriatrics (SCAG), and others.


Frequency of office visits: 4 weeks and 48 hours before fetal precursor cell transplantation, 24 hours after, and then once a week for the first month after fetal precursor transplantation, once a month thereafter.


CASE HISTORY:


G.P., born 1940, a white female, developed an early menopause at the age of 34. At the age of 36 the patient started the hormone replacement therapy of estrogen/progesteron in a program that simulated a menstrual cycle. At the age of 41 she was found to have a mitral valve prolapse, the therapy of which required an avoidance of caffeine and other stimulants, and a regular exercise, but no drugs.


She has been a sportive type all her life, thus besides the appearance, and the subjective evaluation of the mental faculties, the patient has been able to use her physical performance to judge her aging process, too.


In 1989 she observed some lowering of physical stamina, and on physician’s advice took a animal fetal cell transplantation consisting of injection of 9 (nine) various transplants, the primary purpose of which was to support the hormonal system stressed and strained by the premature ovarian failure. Her physician was of the opinion that the hormone replacement therapy did not control sufficiently the generalized hormonal imbalance of the premature menopause.


Prior to cell transplantation her tests showed a normal complete blood count, a normal blood chemistry, a normal cholesterol and triglycerides, normal exercise EKG; while blood estrogen, progesteron, FSH and LH were all at menopausal level, visual acuity showed a minimal presbyopia, and audiogram within normal limits.


Neurological examination was normal, posture and gait was normal, balance was unimpaired, mimicry and gesticulation was vivid, there was no tremor, the grasping of objects was unimpaired.


The psychological evaluation of personality showed normal of initiative, normal drive, normal affection, normal imagination, “sound mind”, normal attention span, lack of depression, absence of insecurity. The psychological evaluation of intellect showed normal thought process, no impairment of comprehension of new ideas, normal concentration, normal memory, normal orientation, normal speech , normal judgment, no impairment of abstract thinking. Patient showed no loss of interest in friends, hobbies, surrounding, politics, etc., continued to be very sociable, and be the “life of the party”. The sexual functioning was normal, libido not diminished.


In 1993 the patient received the 2nd fetal cell transplantation of ovary, placenta, hypothalamus, liver, adrenal cortex, cardiomyoblasts, cartilage, spleen, by our team in Moscow. The indication was to maintain the status quo insofar physical, mental and spiritual functions was concerned.


Prior to the treatment her tests showed a normal complete blood count, a normal blood chemistry, a normal cholesterol and triglycerides, normal exercise EKG; while her blood estrogen, progesteron, FSH and LH were at menopausal level. All other examinations, visual, auditory, neurological and psychological were normal.


In 1995 the patient had an episode of high blood pressure following an attack by a dog, but the blood pressure went back to normal with just sedatives.


Subsequent to that, in 1995 the patient received 3rd cell transplantation of the same 8 transplants by our team in Moscow again. The indication was to maintain the status quo insofar physical, mental and spiritual functions.


Prior to the treatment her tests showed the same findings as always before, and all her examination no change as compared with the previous ones.


In 1998 the patient received 4th transplantation of 10 different stem cell transplants, all those received before, with addition of frontal lobe of brain, bone, of our manufacturing. The indication was to maintain the status quo.


All tests and examinations showed no change.


In March 2000 the measurement of bone density of the whole body revealed values characteristic for a woman of 40 years of age, e.g. 20 years less than the age of the patient.


In October 2001 patient underwent 5th stem cell transplantation of the same 8 transplants of our manufacturing as before.


Note: The above write-up proves the difficulty of presenting a case history of a patient where the indication for fetal precursor cell transplantation is primarily a ‘disease of aging’, even though there are usually some other indications as well, in this case a premature menopause. When you read it, it seems like time has stopped. All that various physicians or psychologists can state that the standard examinations used are within limits of normal. That’s the whole point. The chronological aging clock is “ticking” the way it should, while the biological aging clock appears to have slowed down so that the aging becomes inconspicuous.


How to state medically that a woman of 62 looks, moves, acts, behaves, thinks, etc. like 40 years old, and that no one wants to believe her true age. The human life in its physical, mental and spiritual aspects just cannot be measured. It appears possible to slow down the aging process. And not only seemingly “ageless” movie stars that you see in the movies or on your TV screens can accomplish it.


But it is not only a result of fetal precursor cell transplantations every 3 years or so, but the motion, mimicry, behavior, action, remained that of aged person, etc. Everyone knows that there are no cosmetic surgical procedures for the ‘lifting’ of aging body.


This patient has had a proper nutrition, that she prepared herself most of the time from ecologically sound fresh ingredients, ate a lot of cheese made of raw milk, drank regularly wine without additives and preservatives , but also plenty of real spring water, but not ‘soft drinks’. She exercised regularly, had no problem to go through a 60 minutes’ aerobics/total body fitness class with fit women and men who could be her children or grandchildren. She was mentally active, just finished a supervision of a construction of a new house, that she has never done before in her life. And she has kept her spirits up.